Over a decade ago, the Deadpool Kills the Marvel Universe trilogy began with, well, Deadpool Kills the Marvel Universe by Cullen Bunn,
Dalibor Talajić, Lee Lougridge, and Joe Sabino. Amazingly, Bunn has now turned that series into two SEPARATE and distinct trilogies, with the original "Killogy" extending into Deadpool Killiustrated (Deadpool killing characters in famous works of fiction) and Deadpool Kills Deadpool, and the CURRENT trilogy continuing into Deadpool Kills the Marvel Universe Again, and now, Deadpool Kills the Marvel Universe One Last Time, and in this CBR exclusive preview, we see Deadpool take on a Marvel character who hasn't been used in the comics in over three decades (outside of a cameo appearance in a single panel among a bunch of other obscure characters in The History of the Marvel Universe back in 2011)!
Deadpool Kills the Marvel Universe One Last TIme #1 is from writer Cullen Bunn, artist Dalibor Talajić, colorist Lee Lougridge, and letterer Joe Sabino, the same creative team as the first series back in 2012. In this issue, Deadpool meets John Doe. John Doe was the star of Nth Man: The Ultimate Ninja, who worked with his childhood friend, Alfie O'Meagan, whose powers neutralized all nuclear weapons on Earth, which led to a gigantic World War. The comic was by Larry Hama and Ron Wagner, and took place in its own continuity, and the series was canceled over 30 years ago, but now Deadpool is set to meet John Doe!

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DEADPOOL KILLS THE MARVEL UNIVERSE ONE LAST TIME #1 (OF 5)
CULLEN BUNN (W) • DALIBOR Talajić (A) • Cover by DAVIDE PARATORE
VARIANT COVER BY GREG LAND • VARIANT COVER BY DAN PANOSIAN
VIRGIN VARIANT COVER BY DAN PANOSIAN
VARIANT COVER BY NICK BRADSHAW
HOMAGE VARIANT COVER BY CHAD HARDIN
FOIL VARIANT COVER BY LEINIL FRANCIS YU
THE TRILOGY CONCLUDES!
First, Deadpool killed every hero in the Marvel Universe… Then he killed every hero in another Marvel Universe… Well, now, he’s back, and this time, slaughtering his way through Earth’s Mightiest Heroes won’t be enough! He’s going after the worst of the worst, a whole Multiverse of Marvel’s greatest gone bad. Get ready for world-breaking Hulks, werewolf Captain Americas, and some all-new twisted takes!
The classic universe-slaughtering team of Cullen Bunn (DEADPOOL KILLS THE MARVEL UNIVERSE) and Dalibor Talajić (DEADPOOL KILLS THE MARVEL UNIVERSE AGAIN) reunite to kill everyone one…more…time!
32 PGS./Parental Advisory …$4.99

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In the preview pages, Deadpool is contemplating another universe torn apart by his actions when he is attacked by John Doe, the star of Nth Man: The Ultimate Ninja. Doe gives Deadpool a good fight, but in the end, Deadpool kills him.
As it turns out, the fight was intended as a test by a mysterious being known as Alphea. When he passed it by killing Doe, she offers him a gig. He passes on the offer instantly, but she continues to argue as the preview pages run out. I think we can all assume that she DOES manage to convince him, but we'll find out next week exactly WHAT she wants from Deadpool, and how, exactly, the Marvel Multiverse plays into this new series.
Source: Marvel